Aims: High naevus counts, and UV photodamage are strong melanoma risk factors. However, whole-of-body measures fail to capture variability across body sites. Three-dimensional (3D) total body photography (TBP) and artificial intelligence (AI) allows the opportunity to automate the extraction of site-specific distributions of naevi and photodamage. This study combined 3D-TBP, AI, and unsupervised clustering in a high-risk cohort to identify distinct phenotypic patterns associated with melanoma.
Clinical Publications News
Three-dimensional (3D) total body photography (TBP) offers faster and enhanced skin visualization, potentially improving surveillance of high-risk skin cancer patients. This prospective longitudinal observational study (July 2021-December 2023) aimed to report the clinical outcomes of integrating 3D-TBP with digital dermoscopy for follow-up of high-risk melanoma patients.
Concerning early melanoma detection, dermatologists experience two major challenges: an overwhelming number of patients seeking total body skin examinations, and limited access to a standardized imaging system for monitoring their patients with increased risk for melanoma. This study introduces, for the first time, the concept of an independent imaging center utilizing a three-dimensional (3D) imaging system operated without a dermatologist present on site. The 3D scan performed in low-and mid-risk patients serves as a ‘TRIAGE scan’ to filter the patients who require a dermatology consultation. In high-risk patients, it functions as an ‘ASSIST scan’, assisting dermatologists during follow-up consultations.
Three-dimensional total body photography (3D TBP) is a new tool in dermatology, and its role and value in the diagnosis of skin conditions have been shown for skin malignancies with respectable diagnostic accuracies, but not for other skin diseases.
Background/Objectives: This study aims to evaluate and compare the diagnostic accuracy of skin lesion classification among three different classifiers: AI-based image classification, an expert dermatologist, and a non-expert. Given the rising interest in artificial intelligence (AI) within dermatology, it is crucial to assess its performance against human expertise to determine its viability as a reliable diagnostic tool.
Background: Specific phenotypic traits are known to be associated with an increased risk of developing melanoma. The latest 3-dimensional total body photography systems integrate machine learning tools that automatically describe patients’ skin lesions. The aim of the present study is to describe machine learning outcomes from 3-dimensional total body photography and assess their correlation with phenotypic characteristics.
Importance: Diverse racial and ethnic representation in clinical trials has been limited, not representative of the US population, and the subject of pending US Food and Drug Administration guidance. Psoriasis presentation and disease burden can vary by skin pigmentation, race and ethnicity, and socioeconomic differences. Overall, there are limited primary data on clinical response, genetics, and quality of life in populations with psoriasis and skin of color (SoC). The Varying Skin Tones in Body and Scalp Psoriasis: Guselkumab Efficacy and Safety trial (VISIBLE) is underway and uses strategies aimed at addressing this persistent gap.
Late alopecia, defined as incomplete hair regrowth > 6 months following cytotoxic chemotherapy or > 6 months from initiation of endocrine therapy, negatively impacts quality of life and may affect dose intensity of adjuvant therapy. This study investigates the effect of oral minoxidil in women with chemotherapy and/or endocrine therapy-induced late alopecia.
Hair thinning affects upwards of 50% of women by age 50, impacting their social-emotional wellbeing. It is a condition now thought to be driven by a multi-factorial etiology, including diet and nutrition. Women following vegan, vegetarian, or other plant-based diets have specific needs for nutrients traditionally sourced from animals, which could affect hair health. To support hair growth and quality in women following a plant-based diet, a novel vegan nutraceutical (Nutrafol Women's Vegan Capsules, Nutraceutical Wellness, Inc., New York, NY) was evaluated for its ability to support hair health.
Objective: This study aimed to investigate the reproducibility and accuracy of the Visia® Complexion Analysis Camera System by Canfield Scientific for objective skin analysis.
